TOPMed imputation Server

The TOPMed Imputation Server provides a free genotype imputation service (chromosomes 1-22 and X) using Minimac4. You can upload phased or unphased GWAS genotypes and receive phased and imputed genomes in return. This server offers imputation from the TOPMed reference panel. For all uploaded datasets, comprehensive QC is performed.

Please cite the following papers if you use the TOPMed Imputation Server:

• TOPMed Study:

  Taliun, D. et al. (2019) Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Biorxiv, doi:10.1101/563866

• Imputation Server:

  Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A, Vrieze S, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh PR, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C. Next-generation genotype imputation service and methods. Nature Genetics 48, 1284–1287 (2016).

• Minimac Imputation:

  Fuchsberger, C., Abecasis, G. R., & Hinds, D. A. (2014). minimac2: faster genotype imputation. Bioinformatics, 31(5), 782–784.